Human muscle-derived CLEC14A-positive cells regenerate muscle
independent of PAX7
Stefanie A. Grunwald1,
Muscle Research Unit, Experimental
and Clinical Research Center, a joint cooperation of
Charité, Universitätsmedizin Berlin and the Max
Delbrück Center for Molecular Medicine in the
Helmholtz Association, Berlin, Germany
Max Delbrück Center for Molecular
Medicine in the Helmholtz Association, Berlin,
Systems Biology of Gene-Regulatory
Elements, Berlin Institute of Medical Systems
Biology (BIMSB) at the Max Delbrück Center
for Molecular Medicine in the Helmholtz
Association, Berlin, Germany
Berlin Institute of Health,
Dept. of Nuclear Medicine, Charité
Universitätsmedizin Berlin, Berlin, Germany
INSERM U1179, Université de
Versailles Saint-Quentin-en-Yvelines, Versailles,
Hôpital Universitaire Raymond
Poincare, Garches, France
Dept. of Neurosurgery, HELIOS
Klinikum Berlin-Buch, Berlin, Germany
Corresponding author: Simone Spuler
This online database/tool is created and maintained by
The following features are currently supported in the atlas:
- Clustering of the single-cell RNA sequencing data for the
PAX7 positive and negative populations of every donor
together with the PAX7null. A 2D tSNE representation of the
cell clustering is shown. Clustering can be queried for the expression
of a given gene. Gene symbols are required.
- The clustering is supported from violin plots,
showing expression of the selected genes along the cell clusters.
- The "PAX7pos All Donors" and "PAX7neg All Donors" tabs show the
clusterings of all Donors as shown in the supplement.
The format is the same as described above.
The raw (fastq files), as well as processed data (digital gene expression matrices for each patient)
is available at the GEO database under the accsession number
The normalized counts for the bulk data can be directly
downloaded as an Excel sheet
Genome tracks for every cell population are available
- 19 July 2018: database goes public, genome tracks added.
- 24 May 2018: database goes online.